MYSTERY CASE
DIAGNOSIS CHALLENGE

Hereditary ATTR (hATTR) amyloidosis is an autosomal dominant disease caused by a mutation in the transthyretin (TTR) gene that results in misfolded TTR proteins accumulating as amyloid fibrils in multiple sites including the nerves, heart, and GI tract.1-3 It’s a progressive disease that may eventually rob patients of function—and their lives.1,2,4,5

FOLLOW THE
CLUES AND
SOLVE
THE CASE

Due to the progressive nature of the disease, patients with hATTR amyloidosis require an early and accurate diagnosis.6-8 This tool is designed to help you recognize the red-flag symptoms that indicate when an hATTR amyloidosis diagnosis should be considered.

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References:

  1. Hanna M. Curr Heart Fail Rep. 2014;11(1):50-57.
  2. Damy T, Judge DP, Kristen AV, et al. J Cardiovasc Transl Res. 2015;8(2):117-127.
  3. Hawkins PN, Ando Y, Dispenzeri A, et al. Ann Med. 2015;47(8):625-638.
  4. Adams D, Coelho T, Obici L, et al. Neurology. 2015;85(8):675-682.
  5. Mohty D, Damy T, Cosnay P, et al. Arch Cardiovasc Dis. 2013;106(10):528-540.
  6. Adams D, Suhr OB, Hund E, et al. Curr Opin Neurol. 2016;29(Suppl 1):S14-S26.
  7. Conceição I, Gonzãlez-Duarte A, Obici L, et al. Peripher Nerv Syst. 2016;21(1):5-9.
  8. Obici L, Kuks JB, Buades J, et al. Curr Opin Neurol. 2016;29(suppl 1):S27-S35.
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