GATHER THE DATA
Patient photo
Patient history and presentation
  • 65-year-old African American male
  • History of hypertension
  • Fatigue
  • Lower extremity edema
  • Numbness, tingling in toes, neuropathic pain
  • Shortness of breath, dizziness on exertion
  • Father died of heart failure at age 62
NEXT...NARROW THE FIELD
WHICH OF THE FOLLOWING CONDITIONS
WOULD YOU CONSIDER IN YOUR DIFFERENTIAL DIAGNOSIS?
(Select all that apply)
  • hATTR amyloidosis
  • Amyloid light chain (AL) amyloidosis
  • Hypertrophic cardiomyopathy
  • Hypertensive heart disease
ENTER SELECTIONS
Test Results

Thanks for narrowing down the conditions you would consider. In order to continue toward a diagnosis, here are the results of some tests and labs that were ordered by the case physician:

  • Labs: Elevated NT-proBNP and troponin I; serum and urine negative for monoclonal protein
  • Electrocardiography: Low QRS voltage
  • Echocardiography: LV wall thickness 16 mm at basal anterior septum, 18 mm at anterior wall, granular speckling, indicative of refractile myocardium
  • 99mTc-PYP scintigraphy scan: Grade 3 myocardial radiotracer uptake
MAKE THE CALL Which is the most likely diagnosis?
(Choose one)
Sign up to receive updates about hereditary ATTR amyloidosis from Alnylam Sign Up